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Powerful Antioxidant:Curcumin prevents oxidative stress by inhibiting nitric oxide (NO) production and reducing markers of oxidative damage, such as 3-nitrotyrosine (3-NT).
Strong Anti-Inflammatory Activity:It suppresses the release of histamine and inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8), reducing inflammation in both cellular and animal models.
Antitumor Effects:Curcumin decreases tumor formation in mouse skin and reduces the number of preneoplastic lesions and neoplasms in animal models.
Protective in Allergic and Cardiovascular Conditions:It mitigates histopathological changes in nasal mucosa, reduces symptoms of rhinitis, and shows protective effects against cardiovascular oxidative stress.
Product Description of Curcumin CAS#458-37-7
Curcumin is the primary yellow pigment found in turmeric and curry, known for its antioxidant, anti-inflammatory, and antitumor properties. It effectively inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin also suppresses the release of histamine and inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-8, from HMC-1 mast cells.
In vivo studies show that curcumin lowers serum levels of histamine and TNF-α, prevents histopathological changes in the nasal mucosa, and reduces sneezing and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Additionally, curcumin (100 or 200 mg/kg) inhibits the accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in the hearts of mice. Topical application (1–10 μmol) decreases the number of tumors induced by phorbol 12-myristate 13-acetate (TPA) in mouse skin, while dietary administration reduces tongue neoplasms and preneoplastic lesions caused by 4-nitroquinoline 1-oxide (4-NQO) in rats.
Product Application of Curcumin CAS#458-37-7
Curcumin is a natural phenolic compound with potent anti-tumor, anti-inflammatory, and antioxidant properties. It induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Curcumin has been reported to suppress the production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. It is a strong inhibitor of EGFR tyrosine kinase and IκB kinase, and also inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase, and lipoxygenase.
Curcumin readily penetrates the cytoplasm of cells, accumulating in membranous structures such as the plasma membrane, endoplasmic reticulum, and nuclear envelope, enhancing its biological activity.
Parameters
Safety Information
Delivery Time
Inventory 2-3 working days New manufacturing 7-10 working days
Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
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1. Why Supply Chain Transparency Matters in Global Chemical Procurement
Chemical buyers evaluate more than price and delivery time. Clear specifications, matching batch documents, consistent packaging information, and traceable logistics all affect customs clearance, warehouse inspection, and production use.
When selecting a supplier, buyers should review how the company confirms specifications, manages documents, handles changes, and responds to problems. Transparent processes help reduce order risks and improve long-term procurement reliability.
2. Seven Essential Details for a Chemical Product Inquiry
A product name alone is often insufficient for an accurate quotation. Buyers should provide the product name and CAS number, key specifications or purity, final application, required quantity, packaging requirements, destination, and expected delivery time or preferred Incoterms.
If COA, SDS, TDS, special labels, certifications, or registration documents are required, these details should also be included in the initial inquiry. Complete information helps suppliers confirm product, logistics, and documentation conditions more efficiently.
3. What Are the Differences Between COA, SDS, and TDS?
A COA is a batch-specific Certificate of Analysis showing test items, required ranges, and actual results. It is mainly used for quality verification and incoming inspection.
An SDS provides safety, handling, storage, emergency, and transportation information. A TDS describes typical product properties, technical parameters, and application guidance. Buyers should confirm the required document version, language, and applicable standards before placing an order.
4. Key Conditions to Confirm Before International Chemical Transportation
Before shipment, confirm the product identity, physical form, transport classification, and applicable regulations. An SDS is an important reference, but the final shipping arrangement must also meet regulatory and carrier requirements.
Packaging, sealing, moisture protection, palletizing, labels, ports, documents, Incoterms, and transport schedules should be clearly confirmed. Early verification helps prevent delays caused by carrier restrictions or incomplete documentation.
5. How to Evaluate Chemical Product Sample Test Results
Sample evaluation should consider both product compliance and application performance. Laboratory results do not always guarantee the same performance in every formulation or production process.
Before testing, record the sample batch, COA, storage condition, and sampling method. During application tests, keep consistent records of formulation, dosage, process conditions, and results. After approval, reconfirm the formal order specifications, inspection method, packaging, and batch documents.
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