Acetaminophen CAS#103-90-2

Acetaminophen CAS#103-90-2

Analgesic & Antipyretic Effects‌:Effective pain relief and fever reduction.


Selective COX Inhibition‌:Modulates COX-2 more than COX-1 at high doses.


Metabolic Versatility‌:Generates reactive metabolites with diverse effects.


Animal Model Efficacy‌:Demonstrated therapeutic properties in vivo.


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product description

Products Description of Acetaminophen CAS#103-90-2

Acetaminophen is an analgesic/antipyretic that inhibits COX-2 (83%) and COX-1 (56%) at high 1,000 mg doses. Its toxic metabolite NAPQI causes liver injury by depleting glutathione, and it induces ferroptosis in mouse hepatocytes (reversible by ferrostatin-1). It remains effective for pain and fever relief in animal studies.


Product Applications of Acetaminophen CAS#103-90-2

Acetaminophen (Paracetamol, CAS# 103-90-2) is a non-anti-inflammatory antipyretic/analgesic. Comparable to aspirin in fever relief but weaker in pain relief, it is the top acetanilide derivative ideal for patients intolerant to carboxylic acid drugs. Used for colds and toothaches; also an organic intermediate, H₂O₂ stabilizer and photographic chemical component.

Parameters


Melting point

168-172 °C(lit.)

Boiling point

273.17°C (rough estimate)

density

1,293 g/cm3

vapor pressure

0.008Pa at 25℃

refractive index

1.5810 (rough estimate)

Fp

11 °C

storage temp.

Inert atmosphere,Room Temperature

solubility

ethanol: soluble0.5M, clear, colorless

form

Crystals or Crystalline Powder

pka

9.86±0.13(Predicted)

color

White

Odor

odorless

PH

5.5-6.5 (H2O, 20℃)(saturated solution)

PH Range

5.5 - 6.5 (H?O, 20 °C) (saturated solution)

explosive limit

15%(V)

Water Solubility

14 g/L (20 ºC)

Merck

14,47

BRN

2208089

BCS Class

3,4

Cosmetics Ingredients Functions

SKIN CONDITIONING

InChIKey

RZVAJINKPMORJF-UHFFFAOYSA-N

LogP

1.098 at 25℃

CAS DataBase Reference

103-90-2(CAS DataBase Reference)

IARC

3 (Vol. 50, 73) 1999

NIST Chemistry Reference

Acetaminophen(103-90-2)

EPA Substance Registry System

Acetaminophen (103-90-2)


Safety Information


Hazard Codes

Xn,T,F

Risk Statements

22-36/37/38-52/53-36/38-40-39/23/24/25-23/24/25-11

Safety Statements

26-36-61-37/39-22-45-36/37-16-7

RIDADR

UN 3077 9/PG III

WGK Germany

1

RTECS

AE4200000

Autoignition Temperature

540 °C

TSCA

Yes

HazardClass

9

PackingGroup

III

HS Code

29242930

Hazardous Substances Data

103-90-2(Hazardous Substances Data)

Toxicity

LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson)


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Shipping And Transportation

Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
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