Gentamicin sulfate CAS#1405-41-0

Gentamicin sulfate CAS#1405-41-0

Broad-spectrum bactericidal antibiotic effective against Gram-negative bacteria such as Escherichia coli, Shigella dysenteriae, Klebsiella pneumoniae, Proteus, and Pseudomonas aeruginosa.


Versatile administration routes: suitable for systemic or local infections, oral use for intestinal infections, and ophthalmic use for conjunctivitis and keratitis.


Can be used prophylactically or therapeutically in combination with other antibiotics (e.g., metronidazole or clindamycin) to reduce infection rates in colon surgery.


Shares a similar antibacterial spectrum with kanamycin, making it a reliable option for treating various bacterial infections.



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product description

Product Description of Gentamicin sulfate CAS#1405-41-0

Gentamicin sulfate is a glycoside bactericidal antibiotic with an antibacterial spectrum similar to kanamycin. It mainly treats infections caused by various Gram-negative bacteria. It is used topically for eye inflammation, orally for intestinal infections and preoperative bowel preparation, and combined with other drugs to lower colon surgery infection risks.


Product Application of Gentamicin sulfate CAS#1405-41-0

Gentamicin sulfate treats various bacterial infections induced by susceptible Gram-negative bacteria and staphylococci.
It inhibits bacterial protein synthesis by binding to 30S ribosomal subunit. It also damages bacterial outer membrane to kill pseudomonas. It is widely applied for sepsis, urinary tract infections, endocarditis and other bacterial disorders.

Parameters


Melting point218-237°C
alphaD25 +102°
density1.000 g/cm3
storage temp.2-8°C
solubilityH2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days.
formpowder
colorcolorless to light yellow
Odorodorless
PH4.0-5.5 (0.1g/mL in H2O)
optical activity[α]20/D +110±8°, c = 1% in H2O
biological sourceMicromonospora purpurea
Water SolubilitySoluble in water
Merck134403
InChIKeyRDEIXVOBVLKYNT-HDZPSJEVSA-N
CAS DataBase Reference1405-41-0(CAS DataBase Reference)
EPA Substance Registry SystemGentamicin sulfate (1405-41-0)
Hazard CodesXn
Risk Statements42/43
Safety Statements23-36/37-45-22-24/25
WGK Germany2
RTECSLY2625000
F3
HS Code29419010
ToxicityLD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black)


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