5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine CAS#32779-36-5

Valuable Pharmaceutical Intermediate: Widely used in the synthesis of macitentan, an endothelin receptor antagonist for pulmonary hypertension treatment.


Reactive Halogenated Structure: Contains both chloro and bromo substituents, enabling versatile chemical transformations and functionalization.


High Synthetic Utility: The pyrimidine core structure supports efficient incorporation into complex drug molecules.


Supports Advanced Drug Development: Facilitates the production of targeted therapeutic agents, making it important for modern pharmaceutical research.


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product description

Product Description of 5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is a halogenated pyrimidine derivative featuring chloro and bromo substituents at the 2- and 5-positions of the ring. It is primarily used as a pharmaceutical intermediate in the synthesis of macitentan, an endothelin receptor antagonist employed in the treatment of pulmonary hypertension.


Product Applications of 5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is used as a pharmaceutical intermediate in the synthesis of various drug compounds, including inhibitors. It is also utilized in cross-coupling reactions involving indium organometallic reagents with 2,5-dihalopyrimidines.


Parameters


Melting point73-79 °C (lit.)
Boiling point95°C 15mm
density1.859±0.06 g/cm3(Predicted)
Fp95°C/15mm
storage temp.Keep in dark place,Sealed in dry,Room Temperature
solubilitysoluble in Methanol
pka-2.84±0.22(Predicted)
formCrystalline Powder
colorOff-white to beige
Water Solubilityinsoluble
BRN507955
Stability:Hygroscopic
InChIInChI=1S/C4H2BrClN2/c5-3-1-7-4(6)8-2-3/h1-2H
InChIKeyXPGIBDJXEVAVTO-UHFFFAOYSA-N
SMILESC1(Cl)=NC=C(Br)C=N1
CAS DataBase Reference32779-36-5(CAS DataBase Reference)
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-36/39-37/39-36
RIDADRUN 3335
WGK Germany3
HazardClassIRRITANT
HS Code29335990


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