Metronidazole CAS#443-48-1

Metronidazole CAS#443-48-1

Effective Anti-anaerobic Activity:Metronidazole has strong bactericidal effects against a wide range of anaerobic microorganisms.


Dual-action Mechanism:Both the drug and its metabolites inhibit bacterial DNA synthesis, effectively stopping bacterial growth and reproduction.


Clinically Proven Efficacy:Recognized by the World Health Organization as a key treatment for anaerobic infections with significant therapeutic results.


Broad Therapeutic Applications:Widely used for the prevention and treatment of various infections, including oral, respiratory, gastrointestinal, abdominal, skin, and systemic infections caused by anaerobic bacteri.

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product description

Product Description of Metronidazole CAS#443-48-1

Metronidazole is a nitroimidazole antibiotic active against anaerobic bacteria and Giardia, working by inhibiting bacterial DNA synthesis after metabolic activation. Designated by WHO in 1978 as the drug of choice for anaerobic infections, it was first used for vaginal trichomoniasis and is now widely applied to prevent and treat anaerobic infections throughout the body.


Product Application of Metronidazole CAS#443-48-1

This product has been used since 1959 for the treatment of vaginal trichomoniasis, and since 1970 for intestinal and extraintestinal amoebiasis. It is characterized by high efficacy, low toxicity, and a broad range of applications. However, animal studies have shown potential mutagenic and teratogenic effects.

Metronidazole exhibits strong antibacterial activity against most anaerobic bacteria. It is widely used in the treatment of amoebiasis, trichomoniasis, and various anaerobic infections.


Parameters


Melting point159-161 °C (lit.)
Boiling point301.12°C (rough estimate)
density1.3994 (rough estimate)
refractive index1.5800 (estimate)
Fp9℃
storage temp.2-8°C
solubilityacetic acid: 0.1 M, clear, faintly yellow
formcrystalline
pkapKa 2.62(H2O,t =25±0.2,Iundefined) (Uncertain)
colorwhite to light yellow
Water Solubility<0.1 g/100 mL at 20 ºC
Merck146157
BRN611683
BCS Class1,3
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyVAOCPAMSLUNLGC-UHFFFAOYSA-N
LogP-0.02
IARC2B (Vol. 13, Sup 7) 1987
NIST Chemistry ReferenceMetronidazole(443-48-1)
EPA Substance Registry SystemMetronidazole (443-48-1)
Hazard CodesXn
Risk Statements40-46-45-39/23/24/25-23/24/25-11
Safety Statements36/37-45-53-16-7
WGK Germany3
RTECSNI5600000
F8
HS Code29332990
Hazardous Substances Data443-48-1(Hazardous Substances Data)


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