Products
Potent Tyrosinase Inhibitor:Arbutin effectively inhibits human tyrosinase activity in melanocytes, helping reduce melanin formation and treat hyperpigmentation.
Strong Antioxidant Protection:It protects cells from free radical–induced damage, preventing hemolysis and improving skin fibroblast viability.
Powerful Anti-Inflammatory Activity:Arbutin suppresses inflammatory cytokines (IL-1β, IL-6, TNF-α) in vivo, demonstrating significant anti-inflammatory effects.
Effective Skin Brightening and Depigmenting Agent:Widely used in formulations for hyperpigmentation disorders, supporting skin whitening and tone-evening applications.
Product Description of Arbutin CAS#497-76-7
Arbutin is a glycosylated form of hydroquinone naturally found in Arctostaphylos plants and exhibits a range of biological activities, including tyrosinase inhibition, antioxidant effects, and anti-inflammatory properties. It effectively suppresses human tyrosinase activity in crude enzyme preparations isolated from melanocytes (IC50 values of 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).
At a concentration of 50 μM, arbutin inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes, and at concentrations above 125 μM, it prevents AAPH-induced reductions in cell viability in cultured human skin fibroblasts. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) suppresses increases in IL-1β, IL-6, and TNF-α levels in both lung tissue and serum. Formulations containing arbutin have been widely applied in the treatment of hyperpigmentation disorders.
Product Application of Arbutin CAS#497-76-7
Arbutin is applied in diuretic and anti-infective medications for the urinary system. It is also used as a stabilizer in color photographic developing processes. In cosmetic formulations, arbutin is widely utilized for skin whitening, freckle reduction, and hair care applications.
Parameters
Safety Information
Delivery Time
Inventory 2-3 working days New manufacturing 7-10 working days
Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
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Chemical buyers evaluate more than price and delivery time. Clear specifications, matching batch documents, consistent packaging information, and traceable logistics all affect customs clearance, warehouse inspection, and production use.
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A product name alone is often insufficient for an accurate quotation. Buyers should provide the product name and CAS number, key specifications or purity, final application, required quantity, packaging requirements, destination, and expected delivery time or preferred Incoterms.
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A COA is a batch-specific Certificate of Analysis showing test items, required ranges, and actual results. It is mainly used for quality verification and incoming inspection.
An SDS provides safety, handling, storage, emergency, and transportation information. A TDS describes typical product properties, technical parameters, and application guidance. Buyers should confirm the required document version, language, and applicable standards before placing an order.
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Before shipment, confirm the product identity, physical form, transport classification, and applicable regulations. An SDS is an important reference, but the final shipping arrangement must also meet regulatory and carrier requirements.
Packaging, sealing, moisture protection, palletizing, labels, ports, documents, Incoterms, and transport schedules should be clearly confirmed. Early verification helps prevent delays caused by carrier restrictions or incomplete documentation.
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