Arbutin CAS#497-76-7

Arbutin CAS#497-76-7

Potent Tyrosinase Inhibitor:Arbutin effectively inhibits human tyrosinase activity in melanocytes, helping reduce melanin formation and treat hyperpigmentation.


Strong Antioxidant Protection:It protects cells from free radical–induced damage, preventing hemolysis and improving skin fibroblast viability.


Powerful Anti-Inflammatory Activity:Arbutin suppresses inflammatory cytokines (IL-1β, IL-6, TNF-α) in vivo, demonstrating significant anti-inflammatory effects.


Effective Skin Brightening and Depigmenting Agent:Widely used in formulations for hyperpigmentation disorders, supporting skin whitening and tone-evening applications.


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product description

Product Description of Arbutin CAS#497-76-7

Arbutin is a glycosylated form of hydroquinone naturally found in Arctostaphylos plants and exhibits a range of biological activities, including tyrosinase inhibition, antioxidant effects, and anti-inflammatory properties. It effectively suppresses human tyrosinase activity in crude enzyme preparations isolated from melanocytes (IC50 values of 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).

At a concentration of 50 μM, arbutin inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes, and at concentrations above 125 μM, it prevents AAPH-induced reductions in cell viability in cultured human skin fibroblasts. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) suppresses increases in IL-1β, IL-6, and TNF-α levels in both lung tissue and serum. Formulations containing arbutin have been widely applied in the treatment of hyperpigmentation disorders.


Product Application of Arbutin CAS#497-76-7

Arbutin is applied in diuretic and anti-infective medications for the urinary system. It is also used as a stabilizer in color photographic developing processes. In cosmetic formulations, arbutin is widely utilized for skin whitening, freckle reduction, and hair care applications.


Parameters


Melting point195-198 °C
alpha-64 º (c=3)
Boiling point375.31°C (rough estimate)
density1.3582 (rough estimate)
refractive index-65.5 ° (C=4, H2O)
storage temp.Inert atmosphere,Room Temperature
solubilityH2O: 50 mg/mL hot, clear
formSolid
pka10.10±0.15(Predicted)
colorWhite
optical activity[α]/D -64.0±2.0°, c = 3 in H2O
biological sourcesynthetic or plant
Water Solubility10-15 g/100 mL at 20 ºC
SensitiveHygroscopic
Merck14773
BRN89673
Stability:Stable. Hygroscopic - store under dry nitrogen.
InChIKeyBJRNKVDFDLYUGJ-RMPHRYRLSA-N
LogP-1.35
CAS DataBase497-76-7(CAS DataBase Reference)
Reference
EPA Substance.beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7)



Safety Information


Hazard CodesXn
Risk Statements20/21/22-36/37/38
Safety Statements22-24/25-36-26
WGK Germany3
RTECSCE8863000
F37917
HS Code29389090
Hazardous497-76-7(Hazardous Substances Data)



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